Hematology Practice Exam

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1. In mature erythrocyte, the main purpose of produced NADPH is to be used in(Required)
2. Which of the following pair of statements is not matched for the oxygen dissociation curve(Required)
3. The Kleihauer-Betke test (acid-elution test) is used to detect(Required)
4. Which of the following is the most mature normoblast(Required)
5. Anemia of chronic disease is characterized by all of these except:(Required)
6. A native of Thailand has a normal hemoglobin level. Hemoglobin electrophoresis at pH 8.6 showed 65% HbA and approximately 35% of a hemoglobin at HbA2 position. This is most consistent with hemoglobin(Required)
7. Immunophenotyping for a diagnosis of PNH uses the following monoclonal antibodies: CD55 and CD59 CD11b/CD18 CD33 and CD34 CD56 and CD10(Required)
8. Mean cell volume (MCV) is calculated by using the following formula:(Required)
9. If a patient has a reticulocyte count of 7% and Hct of 20%, what is the corrected reticulocyte count?(Required)
Illustration for question 10
10. Refer to the following illustration: Which area in the automated cell counter histogram represents the RBC distribution curve? A B C D E(Required)
11. In which age group would 60% lymphocytes be a normal finding?(Required)
12. Which is the first stage of erythrocytic maturation in which the cytoplasm is pink because of the formation of Hgb?(Required)
13. Autoagglutination of RBCs at room temperature can cause which of the following abnormal test results?(Required)
14. Spherocytes differ from normal RBCs in all of the following except:(Required)
15. All of the following are usually found in Hgb C disease except:(Required)
16. Which of the following electrophoretic results is consistent with a diagnosis of the sickle cell trait?(Required)
17. Hemolytic uremic syndrome (HUS) is characterized by all of the following except:(Required)
18. Which antibody is associated with paroxysmal cold hemoglobinuria (PCH)?(Required)
19. Microangiopathic hemolytic anemia is characterized by:(Required)
20. A patient’s peripheral blood smear reveals numerous NRBCs, marked variation of RBC morphology, and pronounced polychromasia. In addition to decreased Hgb and decreased Hct values, what other CBC parameters may be anticipated?(Required)
21. IDA may be distinguished from anemia of chronic infection by:(Required)
22. A patient has an Hct of 30%, an Hgb of 8 g/dL, and a RBC count of 4.0 × 1012/L. What is the morphological classification of this anemia?(Required)
23. Which of the following disorders is associated with ineffective erythropoiesis?(Required)
24. Which of the following may be seen in the peripheral blood smear from a patient with obstructive liver disease?(Required)
25. A patient has 80 NRBCs per 100 leukocytes. In addition to increased polychromasia on the peripheral blood smear, what other finding may be present on the CBC?(Required)
26. Which of the following is contained in the primary granules of the neutrophil?(Required)
27. Qualitative and quantitative neutrophil changes noted in response to infection include all of the following except:(Required)
28. The morphological characteristic(s) associated with Chédiak–Higashi syndrome is (are):(Required)
29. The familial condition of Pelger–Huët anomaly is important to recognize because this disorder must be differentiated from:(Required)
30. Neutrophil phagocytosis and particle ingestion are associated with an increase in O2 utilization called respiratory burst. What are the two most important products of this biochemical reaction?(Required)
31. Auer rods may be seen in all of the following except:(Required)
Illustration for question 32
32. Refer to the following illustration: Which area in the automated cell counter histogram represents the lymphocyte curve? A B C D E(Required)
33. Disseminated intravascular coagulation (DIC) is most often associated with which of the following types of acute leukemia?(Required)
34. A 24-year-old man with Down syndrome presents with fever, pallor, lymphadenopathy, and hepatosplenomegaly. His CBC results are as follows: WBC = 10.8 × 109/L, RBC = 1.56 × 1012/L, 8% PMNs, Hgb = 3.3 g/dL, 25% lymphocytes, Hct = 11%, 67% PAS-positive blasts PLT = 2.5 × 109/L These findings are suggestive of:(Required)
35. SITUATION: A peripheral blood smear shows 75% blasts. These stain positive for both Sudan Black B (SBB) and peroxidase. Given these values, which of the following disorders is most likely?(Required)
36. In myeloid cells, the stain that selectively identifies phospholipid in the membranes of both primary and secondary granules is:(Required)
37. Sodium fluoride may be added to the naphthyl ASD acetate (NASDA) esterase reaction. The fluoride is added to inhibit a positive reaction with:(Required)
38. Which of the following reactions are often positive in ALL but are negative in AML?(Required)
39. A patient’s peripheral blood smear and bone marrow both show 70% blasts. These cells are negative on SBB staining. Given these data, which of the following is the most likely diagnosis?(Required)
40. The WHO classification requires what percentage for the blast count in blood or bone marrow for the diagnosis of AML?(Required)
41. What would be the most likely designation by the WHO for AML M2 by the FAB classification?(Required)
Illustration for question 42
42. The large cell indicated by the arrow in the photomicrograph is Myeloblast Promyelocyte Myelocyte Metamyelocyte(Required)
43. Leukocyte alkaline phosphatase (LAP) staining performed on a patient gives the following results: 10(0) 48(1+) 38(2+) 3(3+) 1(4+) Calculate the LAP score.(Required)
44. CML is distinguished from leukemoid reaction by which of the following?(Required)
45. What is the characteristic finding seen in the peripheral blood smear from a patient with multiple myeloma?(Required)
46. Cells that exhibit positive staining with acid phosphatase and are not inhibited by tartaric acid are characteristically seen in:(Required)
47. A 19-year-old man came to the emergency department with severe joint pain, fatigue, cough, and fever. Review the following laboratory results: WBCs 21.0 × 109/L, RBCs 3.23 × 1012/L, Hgb 9.6 g/dL, PLT 252 × 109/L Differential: 17 band neutrophils; 75 segmented neutrophils; 5 lymphocytes; 2 monocytes; 1 eosinophil; 26 NRBCs. What is the corrected WBC count?(Required)
48. A manual WBC count is performed. Eighty WBCs are counted in the four large corner squares of a Neubauer hemacytometer. The dilution is 1:100. What is the total WBC count?(Required)
Illustration for question 49
49. Review the scatterplot of WBCs shown. Which section of the scatterplot denotes the number of monocytes?(Required)
50. A 25-year-old woman presented with symptoms of jaundice, acute cholecystitis, and an enlarged spleen. On investigation, numerous gallstones were discovered. Review the following CBC results: WBC = 11.1 × 109/L MCV = 100 fL RBC = 3.33 × 1012/L MCH = 34.5 pg Hgb = 11.5 g/dL MCHC = 37.5% Hct = 31.6 mL/dL PLT = 448 × 109/L WBC differential: 13 band neutrophils; 65 segmented neutrophils; 15 lymphocytes; 6 monocytes; 1 eosinophil RBC morphology: 3+ spherocytes, 1+ polychromasia What follow-up laboratory test would provide valuable information for this patient?(Required)
51. False-positive results may occur in the screening solubility test for hemoglobin S due to(Required)
52. Which of the following contain RNA and are usually identified by staining with brilliant cresyl blue or new methylene blue?(Required)
53. Which characteristic differentiates the myelocyte from other myelocytic cells?(Required)
54. Many schistocytes are seen on a peripheral blood smear. One of the most common causes for these cells is(Required)
55. Which one of the following hypochromic anemias is usually associated with a normal free erythrocyte protoporphyrin level?(Required)
56. The background of a peripheral blood smear stained with Romanowskytype stain appears very blue. The RBCs are stacked like coins. Fifteen percent of the WBCs are the size of a small lymphocyte with very blue cytoplasm. The nucleus is eccentric and there is a clear area next to it. These cells should be reported as(Required)
57. Specimens for leukocyte alkaline phosphatase stain will yield the most reliable results if smears are made from(Required)
Illustration for question 58
58. Refer to the following illustration: Which curve represents the production of gamma polypeptide chains of hemoglobin? A B C D(Required)
59. All of the findings listed below may be seen in acquired hemolytic anemias of the autoimmune variety. The one considered to be the most characteristic is:(Required)
60. Which of the following are found in association with megaloblastic anemia?(Required)
61. The M:E ratio in erythroleukemia is usually:(Required)
62. Which of the following is NOT a characteristic of hemoglobin H?(Required)
63. When using an electronic cell counter, which of the following results can occur in the presence of a cold agglutinin?(Required)
64. Which of the following stains can be used to differentiate siderotic granules (Pappenheimer bodies) from basophilic stippling?(Required)
65. Terminal deoxynucleotidyl transferase (TdT) is a marker found on:(Required)
66. The Philadelphia chromosome is formed by a translocation between the:(Required)
67. Which of the following is associated with pseudo-Pelger-Huét anomaly?(Required)
68. Increased numbers of basophils are often seen in:(Required)
69. Which of the following is most closely associated with acute promyelocytic leukemia?(Required)
70. Which of the following is associated with Alder-Reilly inclusions?(Required)
71. patient has the following blood values: RBC: 6.5 x 109/uL Hgb: 13.0 g/dL Hct: 39.0% MCV: 65 fL MCH: 21.5 Pg MCHC: 33% These results are compatible with:(Required)
Illustration for question 72
72. Refer to the following pattern Which pattern is consistent with beta-thalassemia major?(Required)
73. Which of the following is associated with May-Hegglin anomaly?(Required)
74. Of the following, the disease most closely associated with glucocerebrosidase deficiency is:(Required)
75. Patients with chronic granulomatous disease suffer from frequent pyogenic infections due to the inability of:(Required)
76. A clotted EDTA tube can be used to perform a(n)(Required)
77. Cytochemical stains were performed on bone marrow smears from an acute leukemia patient. All blasts were periodic acid-Schiff (PAS) negative. The majority of the blasts showed varying amounts of Sudan black B positivity. Some of the blasts stained positive for naphthol AS-D acetate esterase, some were positive for naphthol AS-D chloroacetate esterase, and some blasts _ stained positive for both esterases. What type of leukemia is indicated?(Required)
78. The myeloid progenitor cell can produce cells committed to(Required)
79. When acanthocytes are found on the blood smear, it is usually the result of(Required)
Illustration for question 80
80. Refer to the following illustration: Which area in the automated cell counter histogram represents the platelets curve? A B C D E(Required)
81. In regard to variant hemoglobin E, α2β2 26Glu→Lys , ,which of the following statements is false?(Required)
82. A cellulose acetate hemoglobin electrophoresis (alkaline pH), performed on the blood of a stillborn infant, revealed asingle band that migrated farther towardthe anode than did the Hb A control. Whatis the most likely composition of thestillborn infant's hemoglobin?(Required)
83. A cellulose acetate electrophoresisrevealed a large band of hemoglobin inthe hemoglobin S position. This band quantified at 95%. The peripheral smear revealed 70% target cells, and the solubility test was negative. Based on this information, what is the hemoglobin?(Required)
84. A clinical laboratory scientist received a 5 mL EDTA tube that contained 0.5 mLof anticoagulated blood. A smear was prepared and stained with Wright's stain.When examined microscopically, the majority of cells appeared to have many evenly distributed, blunt spicules on thesurface. How should this cellular appearance be interpreted?(Required)
85. Coarse PAS positivity may be found in the leukemic cells of(Required)
86. Naphthol AS-D chloroacetate esterase(specific) is usually positive incells, and alphanaphthylacetate esterase (nonspecific)is useful for identifying blast cells oflineage.(Required)
87. A bone marrow with 90% cellularity and myeloid:erythroid (M:E) ratio of 10:1 ismost characteristic of(Required)
88. Which of the following is not a characteristicfinding in polycythemia vera?(Required)
89. To best preserve cellular morphology,differential smears from an EDTAspecimen should be made no more thanhour(s) after collection.(Required)
90. The components of Wright's stain include(Required)
91. Which of the following red cell inclusionsstain with both Perl's Prussian blue andWright's stain?(Required)
92. What is the depth between the countingplatform and the coverslip on a hemacytometer?(Required)
93. Side angle scatter in a laser-based cell counting system is used to measure(Required)
94. Hemolysis in paroxysmal nocturnal hemoglobinuria (PNH) is:(Required)
95. Which of the following can differentiate metamyelocytes from other stages of granulocyte maturation?(Required)
96. A patient has a WBC count of 150.0 x 10°/L. On the 100-cell differential, 10% of the cells exhibit a slightly off-center nucleus with a fine chromatin pattern. Several of these cells have nucleoli. The cytoplasm is dark blue with red granules that cover the nucleus. These cells are most likely(Required)
97. What protein is commonly defective in hereditary elliptocytosis Ankyrin Spectrin Band 4.1 Elliptocin(Required)
Illustration for question 98
98. The red blood cells in this image is representative of an anemia that is Microcytic, hypochromic Megaloblastic macrocytic Normocytic, normochromic Myelodysplastic(Required)
Illustration for question 99
99. Which area in the histogram shown for an automated hematology analyzer represents the RBCs distribution curve a b c d(Required)
Illustration for question 100
100. Inclusions in the cytoplasm of neutrophils as shown in the photomicrograph are known as Auer rods Howell-Jolly bodies Heinz-Bodies Dohle bodies(Required)